Como Normalizar O SHBG?

SHBG é a abreviação de Sex Hormone-Binding Globulin, que significa globulina de ligação de hormônios sexuais. Ela é uma proteína transportadora, que é produzida pelo fígado e que serve para regular a quantidade de esteroides (testosterona, dihidrotestosterona (DHT) e estrogênio) no sangue. Embora sejam hormônios distintos, eles também agem de forma combinada para equilibrar algumas funções no corpo.

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Um simples exame pode indicar se os níveis estão altos ou baixos demais, e a partir daí uma investigação pode ser realizada para evidenciar uma possível causa subjacente que esteja desencadeando esse descontrole.

Weight loss from either a higher-protein/low-fat diet or a higher-carbohydrate/low-fat diet increased SHBG levels in a clincal trial on over 100 overweight and obese men [131].

Treatment with the aromatase blockers risedronate (35 mg/week) or letrozole (2.5 mg/day) increased SHBG levels in two clinical trials on over 100 men and women [147, 148].

SHBG e a pílula, o adesivo e o anel vaginal

The conditions we discuss here are commonly associated with low SHBG levels, but this single symptom is not enough for a diagnosis. Work with your doctor to discover what underlying conditions might be causing your low levels of this protein and to develop an appropriate plan to improve your health.

A study on 27 obese men found that a low-fat, high-fiber diet, with exercise, effectively increased SHBG levels [138].

SHGB FAQs

Abnormally high or low SHBG levels can cause problems, because they influence the proportion of sex hormones that are biologically active. Such imbalances can disturb the delicate hormonal ecosystems that our bodies have in place.

Your provider will usually look at your SHBG blood test results along with the results of a total testosterone test. This helps your provider estimate how much free testosterone is in your blood.

High testosterone levels are normally considered to reduce SHBG production. The addition of testosterone blocked SHBG production in two cell studies [70, 71].

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Why do I need an SHBG blood test?

In adult males, testosterone controls sex drive, maintains muscle mass, and helps make sperm. In adult females, testosterone is important for healthy organs and the growth of bones and muscles. Measuring SHBG levels can provide information about how much of your testosterone is active in the tissues of your body.

Ainda que esteja claro que alterações no SHBG podem causar problemas, é importante examinar o motivo dos níveis de SHBG estarem altos ou baixos demais, o que significa buscar e tratar a causa subjacente. Isso é fundamental para conseguir sanar o problema. Por exemplo, se você tem uma doença na tireoide, isso pode estar interferindo diretamente nos seus níveis de SHBG.

Baixos níveis de SHBG: como eles afetam o corpo? Efeitos & associações

Insulin sensitivity, the opposite of insulin resistance seen with diabetes, was associated with high SHBG levels in three studies on over 300 people [102, 103, 104].

In a study on 47 women with polycystic ovarian syndrome (PCOS), high blood insulin levels were linked to low SHBG concentration [59].

Esteroides são hormônios produzidos pelo córtex da suprarrenal (ou pelas gônadas), e tem dentre suas funções o controle metabólico e características sexuais.

What does SHBG do?

Various hormonal disorders, genetic mutations, and liver conditions are believed to cause SHBG to decrease. Low SHBG has been linked to metabolic diseases (like diabetes), breast cancer, heart disease, and PCOS. Physical exercise, caffeine, weight loss, certain dietary changes, and some pharmaceutical drugs may increase SHBG.